Computer Science
Scientific paper
Feb 2004
adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=2004spie.5251..162p&link_type=abstract
Detectors and Associated Signal Processing. Edited by Chatard, Jean-Pierre; Dennis, Peter N. J. Proceedings of the SPIE, Volume
Computer Science
Scientific paper
For sensitive fluorescence detection requiring weak signal recovery, we propose a novel digital synchronous detection method. It is based on a voltage/time duality concept which, compared to a conventional approach, consists of transformation of constant sampling rate with voltage measurement into variable-time sampling with constant threshold voltage. This Variable-Time Synchronous Detection (VTSD) method ensures a constant SNR over a large dynamic range, with optimised measuring rate. It can be implemented without any precise analogue-to-digital converter. A CMOS photodetection system with implementation of this VTSD method together with charge amplification is designed and tested. The results confirm its ability to recover photocurrent signals at femto-Ampers levels.
Lu Guo Neng
Pitaval Michel
Pittet Patrick
Quiquerez Laurent
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