The synthesis and chromatography of peptide nitriles

Details The synthesis and chromatography of peptide nitriles The synthesis and chromatography of peptide nitriles

Dec 1977

adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=1977orli....8..347k&link_type=abstract

Origins of Life, Volume 8, Issue 4, pp.347-353

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Scientific paper

Di- and tripeptide nitriles, glycylaminoacetonitrile (Gly-AAN), diglycylaminoacetonitrile (Gly-Gly-AAN), alanyl-α-aminopropionitrile (Ala-APN), and dialanyl-α-aminopropionitrile (Ala-Ala-APN) were synthesized first. These peptide nitriles and related peptides and peptide amides were analyzed by means of ion-exchange chromatography. The every two diastereomers of dialanine, dialanine amide, and Ala-APN were separated into two peaks by using a pH 3.25 buffer as an eluent. The four isomers of trialanine, trialanine amide, and Ala-Ala-APN gave four, two, and one peak, respectively under the same conditions. The trimethylsilyl derivatives of alanyl peptides and related compounds were analyzed by means of gas chromatography combined with mass-spectrometry. The parent (M+ and/or M+-15) and other mass numbers observed in their mass-spectra supported the introduction of various numbers of trimethylsilyl groups.

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