Peptide nucleic acid (PNA): A model structure for the primordial genetic material?

Details Peptide nucleic acid (PNA): A model structure for the primordial genetic material? Peptide nucleic acid (PNA): A model structure for the primordial genetic material?

Dec 1993

adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=1993oleb...23..323n&link_type=abstract

Origins of Life and Evolution of the Biosphere, Volume 23, Issue 5-6, pp. 323-327

Computer Science

12

Scientific paper

It is proposed that the primordial genetic material could have been peptide nucleic aicds,i.e., DNA analogues having a peptide backbone. PNA momomers based on the amino acid, α, γ-diaminobutyric acid or ornithine are suggested as compounds that could have been formed in the prebiotic soup. Finally, the possibility of a PNA/RNA world is presented, in which PNA constitutes the stable genetic material, while RNA which may be polymerized using the PNA as template accounts for enzymatic activities including PNA replication.

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