The limits of template-directed synthesis with nucleoside-5'-phosphoro(2-methyl)imidazolides

Details The limits of template-directed synthesis with nucleoside-5'-phosphoro(2-methyl)imidazolides The limits of template-directed synthesis with nucleoside-5'-phosphoro(2-methyl)imidazolides

Dec 1993

adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=1993oleb...23..285h&link_type=abstract

Origins of Life and Evolution of the Biosphere, Volume 23, Issue 5-6, pp. 285-290

Other

8

Scientific paper

In earlier work we have shown that C-rich templates containing isolated A, T or G residues and short oligo(G) sequences can be copied effectively using nucleoside-5'-phosphoro(2-methyl)imida-zolides as substrates. We now show that isolated A or T residues within an oligo(G) sequence are a complete block to copying and that an isolated C residue is copied inefficiently. Replication is possible only if there are two complementary oligonucleotides each of which acts as a template to facilitate the synthesis of the other. We emphasize the severity of the problems that need to be overcome to make possible non-enzymatic replication in homogeneous aqueous solution. We conclude that an efficient catalyst Was involved in the origin of polynucleotide replication.

Affiliated with

Also associated with

No associations

Rating

The limits of template-directed synthesis with nucleoside-5'-phosphoro(2-methyl)imidazolides does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.

If you have personal experience with The limits of template-directed synthesis with nucleoside-5'-phosphoro(2-methyl)imidazolides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and The limits of template-directed synthesis with nucleoside-5'-phosphoro(2-methyl)imidazolides will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFWR-SCP-O-1301052