Mathematics – Logic
Scientific paper
Mar 2004
adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=2004spie.5275..204m&link_type=abstract
BioMEMS and Nanotechnology. Edited by Nicolau, Dan V. Proceedings of the SPIE, Volume 5275, pp. 204-212 (2004).
Mathematics
Logic
Scientific paper
We explored the potential for use of the contractile proteins, actin and myosin, as biosensors of solutions containing mercury ions. We demonstrate that the reaction of HgCl2 with myosin rapidly inhibits actin-activated myosin ATPase activity. Mercuric ions inhibit the in vitro analog of contraction, namely the ATP-initiated superprecipitation of the reconstituted actomyosin complex. Hg reduces both the rate and extent of this reaction. Direct observation of the propulsive movement of actin filaments (10 nm in diameter and 1 μm long) in a motility assay driven by a proteolytic fragment of myosin (heavy meromyosin or HMM) is also inhibited by mercuric ions. Thus, we have demonstrated the biochemical, biophysical and nanotechnological basis of what may prove to be a useful nano-device.
Buljan Vlado
dos Remedios Cristobal G.
Kekic Murat
Martinez Rafael
Nicolau Dan V.
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