Directed Molecular Evolution

Details Directed Molecular Evolution Directed Molecular Evolution

Aug 1999

adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=1999oleb...29..425h&link_type=abstract

Origins of Life and Evolution of the Biosphere, v. 29, Issue 4, p. 425-435 (1999).

Computer Science

1

Scientific paper

We propose the existence of a relationship of stereochemical complementarity between gene sequences that code for interacting components: nucleic acid-nucleic acid, protein-protein and protein-nucleic acid. Such a relationship would impose evolutionary constraints on the DNA sequences themselves, thus retaining these sequences and governing the direction of the evolutionary process. Therefore, we propose that prebiotic, template-directed autocatalytic synthesis of mutally cognate peptides and polynucleotides resulted in their amplification and evolutionary conservation in contemporary prokaryotic and eukaryotic organisms as a genetic regulatory apparatus. If this proposal is correct, then the relationships between the sequences in DNA coding for these interactions constitute a life code of which the genetic code is only one aspect of the many related interactions encoded in DNA.

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