Computer Science
Scientific paper
Oct 2001
adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=2001spie.4512..246n&link_type=abstract
Proc. SPIE Vol. 4512, p. 246-254, Complex Adaptive Structures, William B. Spillman; Ed.
Computer Science
Scientific paper
A concept to sequence DNA without tagging the molecule is developed. The fabrication process is compatible with current microelectronics and (emerging) soft-material fabrication technologies, allowing the method to be integrable with MEMS and lab-on-a-chip devices. The preliminary results indicate sensitivity in the nano-gram regime for 100 micron-square pixels. The technology can be extended to perform combinatorial analysis with on-line measurement in real-time during the hybridization process.
Niu Sanjun
Saraf Ravi F.
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