Biology – Quantitative Biology – Populations and Evolution
Scientific paper
2012-02-11
Biology
Quantitative Biology
Populations and Evolution
25 pages, 1 figure
Scientific paper
Phylogenetic mixture models, in which the sites in sequences undergo different substitution processes along the same or different trees, allow the description of heterogeneous evolutionary processes. As data sets consisting of longer sequences become available, it is important to understand such models, for both theoretical insights and use in statistical analyses. Some recent articles have highlighted disturbing ``mimicking'' behavior in which a distribution from a mixture model is identical to one arising on a different tree or trees. Other works have indicated such problems are unlikely to occur in practice, as they require very special parameter choices. After surveying some of these works on mixture models, we give several new results. In general, if the number of mixture components is not too large, and we disallow zero or infinite branch lengths, then mimicking does not occur. On the other hand, if the mixture model is locally over-parameterized, it is possible for a phylogenetic mixture model to mimic distributions of another tree model. Though theoretical questions remain, these sorts of results can serve as a guide to when the use of mixture models in either ML or Bayesian frameworks is likely to lead to statistically consistent inference.
Allman Elizabeth S.
Rhodes John A.
Sullivant Seth
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