Biology – Quantitative Biology – Cell Behavior
Scientific paper
2008-11-25
Nat Cell Biol 10, 8 (2008) 883-5
Biology
Quantitative Biology
Cell Behavior
Scientific paper
10.1038/ncb0808-883
Endothelial barrier function requires the adhesive activity of VE-cadherin and claudin-5, which are key components of adherens and tight endothelial junctions, respectively. Emerging evidence suggests that VE-cadherin controls claudin-5 expression by preventing the nuclear accumulation of FoxO1 and -catenin, which repress the claudin-5 promoter. This indicates that a crosstalk mechanism operates between these junctional structures.
Gavard Julie
Gutkind Silvio J.
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