Biology – Quantitative Biology – Tissues and Organs
Scientific paper
2005-06-27
J. Theor. Biol. 241, 903 (2006)
Biology
Quantitative Biology
Tissues and Organs
30 pages, 11 figures (higher resolution at http://www.uni-saarland.de/fak7/rieger/HOMEPAGE/BJ0.pdf)
Scientific paper
10.1016/j.jtbi.2006.01.022
The transformation of the regular vasculature in normal tissue into a highly inhomogeneous tumor specific capillary network is described by a theoretical model incorporating tumor growth, vessel cooption, neo-vascularization, vessel collapse and cell death. Compartmentalization of the tumor into several regions differing in vessel density, diameter and in necrosis is observed for a wide range of parameters in agreement with the vessel morphology found in human melanoma. In accord with data for human melanoma the model predicts, that microvascular density (MVD, regarded as an important diagnostic tool in cancer treatment, does not necessarily determine the tempo of tumor progression. Instead it is suggested, that the MVD of the original tissue as well as the metabolic demand of the individual tumor cell plays the major role in the initial stages of tumor growth.
Bartha Katalin
Rieger Heiko
No associations
LandOfFree
Vascular network remodeling via vessel cooption, regression and growth in tumors does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.
If you have personal experience with Vascular network remodeling via vessel cooption, regression and growth in tumors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Vascular network remodeling via vessel cooption, regression and growth in tumors will most certainly appreciate the feedback.
Profile ID: LFWR-SCP-O-434689