Vascular biology in altered gravity conditions

Details Vascular biology in altered gravity conditions Vascular biology in altered gravity conditions

Oct 2005

adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=2005esasp1290..352b&link_type=abstract

In: Microgravity applications programme: Successful teaming of science and industry. Edited by Andrew Wilson, coordination: Benn

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The physical environment of Endothelial Cells profoundly affects their gene expression, structure, function, growth differentiation and apoptosis. However, the mechanisms by which the genetic and local growth determinants driving morphogenesis are established and maintained remain unknown. Understanding how gravity affects vascular cells will offer new insights for novel therapeutical approaches for cardiovascular disease in general. In terms of tissue engineering and stem-cell therapy, significant future developments will depend on a profound understanding of the cellular and molecular basis of angiogenesis and of the biology of circulating Endothelial Precursor Cells. this MAP project has demonstrated how modelled microgravity influences endothelial proliferation and differentiation with the involvement of anti-angiogenic factors that may be responsible for the non-spontaneous formation of blood vessels.

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