Transcriptional pulsing and consequent stochasticity in gene expression

Details Transcriptional pulsing and consequent stochasticity in gene expression Transcriptional pulsing and consequent stochasticity in gene expression

2007-11-07

arxiv.org/abs/0711.1141v1

Biology

Quantitative Biology

Quantitative Methods

12 pages, 6 figures. Submitted to PloS Computational Biology on 10/04/2007

Scientific paper

Transcriptional pulsing has been observed in both prokaryotes and eukaryotes and plays a crucial role in cell to cell variability of protein and mRNA numbers. The issue is how the time constants associated with episodes of transcriptional bursting impact cellular mRNA and protein distributions and reciprocally, to what extent experimentally observed distributions can be attributed to transcriptional pulsing. We address these questions by investigating the exact time-dependent solution of the Master equation for a transcriptional pulsing model of mRNA distributions. We find a plethora of results: we show that, among others, bimodal and long-tailed (power law) distributions occur in the steady state as the rate constants are varied over biologically significant time scales. Since steady state distributions may not be reached experimentally we present results for the time evolution of the distributions. Because cellular behavior is essentially determined by proteins, we investigate the effect of the different mRNA distributions on the corresponding protein distributions. We delineate the regimes of rate constants for which the protein distribution mimics the mRNA distribution and those for which the protein distribution deviates significantly from the mRNA distribution.

Affiliated with

Also associated with

No associations

Rating

Transcriptional pulsing and consequent stochasticity in gene expression does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.

If you have personal experience with Transcriptional pulsing and consequent stochasticity in gene expression, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Transcriptional pulsing and consequent stochasticity in gene expression will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFWR-SCP-O-502827