Transcription factor search for a DNA promoter in a three-states model

Details Transcription factor search for a DNA promoter in a three-states model Transcription factor search for a DNA promoter in a three-states model

2011-04-12

arxiv.org/abs/1104.2204v1

Biology

Quantitative Biology

Subcellular Processes

4 pages, 3 figures

Scientific paper

To ensure fast gene activation, Transcription Factors (TF) use a mechanism known as facilitated diffusion to find their DNA promoter site. Here we analyze such a process where a TF alternates between 3D and 1D diffusion. In the latter (TF bound to the DNA), the TF further switches between a fast translocation state dominated by interaction with the DNA backbone, and a slow examination state where interaction with DNA base pairs is predominant. We derive a new formula for the mean search time, and show that it is faster and less sensitive to the binding energy fluctuations compared to the case of a single sliding state. We find that for an optimal search, the time spent bound to the DNA is larger compared to the 3D time in the nucleus, in agreement with recent experimental data. Our results further suggest that modifying switching via phosphorylation or methylation of the TF or the DNA can efficiently regulate transcription.

Affiliated with

Also associated with

No associations

Rating

Transcription factor search for a DNA promoter in a three-states model does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.

If you have personal experience with Transcription factor search for a DNA promoter in a three-states model, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Transcription factor search for a DNA promoter in a three-states model will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFWR-SCP-O-731047