Traffic of cytoskeletal motors with disordered attachment rates

Details Traffic of cytoskeletal motors with disordered attachment rates Traffic of cytoskeletal motors with disordered attachment rates

2008-06-24

arxiv.org/abs/0806.3845v2

Phys. Rev. E 81, 031929 (2010)

Biology

Quantitative Biology

Subcellular Processes

15 pages, 13 figures; revised version (to appear in Phys. Rev. E)

Scientific paper

10.1103/PhysRevE.81.031929

Motivated by experimental results on the interplay between molecular motors and tau proteins, we extend lattice-based models of intracellular transport to include a second species of particle which locally influences the motor-filament attachment rate. We consider various exactly solvable limits of a stochastic multi-particle model before focusing on the low-motor-density regime. Here, an approximate treatment based on the random walk behaviour of single motors gives good quantitative agreement with simulation results for the tau-dependence of the motor current. Finally, we discuss the possible physiological implications of our results.

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