Towards Solving the Inverse Protein Folding Problem

Details Towards Solving the Inverse Protein Folding Problem Towards Solving the Inverse Protein Folding Problem

2010-08-29

arxiv.org/abs/1008.4938v1

Biology

Quantitative Biology

Quantitative Methods

22 pages, 11 figures

Scientific paper

Accurately assigning folds for divergent protein sequences is a major obstacle to structural studies and underlies the inverse protein folding problem. Herein, we outline our theories for fold-recognition in the "twilight-zone" of sequence similarity (<25% identity). Our analyses demonstrate that structural sequence profiles built using Position-Specific Scoring Matrices (PSSMs) significantly outperform multiple popular homology-modeling algorithms for relating and predicting structures given only their amino acid sequences. Importantly, structural sequence profiles reconstitute SCOP fold classifications in control and test datasets. Results from our experiments suggest that structural sequence profiles can be used to rapidly annotate protein folds at proteomic scales. We propose that encoding the entire Protein DataBank (~1070 folds) into structural sequence profiles would extract interoperable information capable of improving most if not all methods of structural modeling.

Affiliated with

Also associated with

No associations

Rating

Towards Solving the Inverse Protein Folding Problem does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.

If you have personal experience with Towards Solving the Inverse Protein Folding Problem, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Towards Solving the Inverse Protein Folding Problem will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFWR-SCP-O-312487