Towards in vivo monitoring of neutron distributions for quality control of BNCT

Details Towards in vivo monitoring of neutron distributions for quality control of BNCT Towards in vivo monitoring of neutron distributions for quality control of BNCT

Apr 2002

adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=2002pmb....47.1059v&link_type=abstract

Physics in Medicine and Biology, Volume 47, Issue 7, pp. 1059-1072 (2002).

Biology

Scientific paper

Dose delivery in boron neutron capture therapy (BNCT) is complex because several components contribute to the dose absorbed in tissue. This dose is largely determined by local boron concentration, thermal neutron distribution and patient positioning. In vivo measurements of these factors would considerably improve quality control and safety. During therapy, a γ-ray telescope measures the γ-rays emitted following neutron capture by hydrogen and boron in a small volume of the head of a patient. Scans of hydrogen γ-ray emissions could be used to verify the actual distribution of thermal neutrons during neutron irradiation. The method was first tested on different phantoms. These measurements showed good agreement with calculations based on thermal neutron distributions derived from a treatment planning program and from Monte Carlo N-particle (MCNP) simulations. Next, the feasibility of telescope scans during patient irradiation therapy was demonstrated. Measurements were reproducible between irradiation fractions. In theory, this method can be used to verify the positioning of the patient in vivo and the delivery of thermal neutrons in tissue. However, differences between measurements and calculations based on a routine treatment planning program were observed. These differences could be used to refine the treatment planning. Further developments will be necessary for this method to become a standard quality control system.

Affiliated with

Also associated with

No associations

Rating

Towards in vivo monitoring of neutron distributions for quality control of BNCT does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.

If you have personal experience with Towards in vivo monitoring of neutron distributions for quality control of BNCT, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Towards in vivo monitoring of neutron distributions for quality control of BNCT will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFWR-SCP-O-1589047