Time and length scales of autocrine signals in three dimensions

Details Time and length scales of autocrine signals in three dimensions Time and length scales of autocrine signals in three dimensions

2007-09-22

arxiv.org/abs/0709.3602v1

Biophys J. 2007 Sep 15;93(6):1917-22

Biology

Quantitative Biology

Quantitative Methods

15 pages

Scientific paper

10.1529/biophysj.107.109736

A model of autocrine signaling in cultures of suspended cells is developed on the basis of the effective medium approximation. The fraction of autocrine ligands, the mean and distribution of distances traveled by paracrine ligands before binding, as well as the mean and distribution of the ligand lifetime are derived. Interferon signaling by dendritic immune cells is considered as an illustration.

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