Biology – Quantitative Biology – Genomics
Scientific paper
2006-11-08
Biology
Quantitative Biology
Genomics
This paper has been withdrawn by the author just to be on the safe side- it is valid and correct, but has certain overlap with
Scientific paper
Significant fraction (about 98.5% in humans, 24% in microbe Rickettsia prowazekii) of most animal genomes is non-coding DNA. Although recent studies established functions of its certain portions, it remains genomic dark matter. The paper unravels its unusual nature with time reversal approach. Any genome emerged in evolutionary selection of the fittest survivors. Survivability of modern species is extensively quantified. Accurate analysis establishes that under specified conditions it is dominated by the same law in species from human to single-cell yeast. Since all violators of the law perished in the previous evolution, it presents the exact law of unanticipated universal (rather than species specific natural) evolutionary selection of survivors. The law implies their rapid hereditary, thus genetic, adaptation which is navigated by operating system of non-coding DNA. Such adaptation to drastic environmental changes was a must for survival, thus evolved, in otherwise lethal major mass extinctions. Navigator genome allows for rapid, artificial included, biological changes (e.g., Methuselah lifespan). Universal law establishes biological relativity to age transformation in any species; quantifies applicability of animal models to humans; implies certain universality in biological complexity and reduces it to exact science problem. Evolutionary and experimental data corroborate all above conclusions. Further theoretical study and test-stone experiments are suggested.
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