Theory of DNA translocation through narrow ion channels and nanopores with charged walls

Details Theory of DNA translocation through narrow ion channels and nanopores with charged walls Theory of DNA translocation through narrow ion channels and nanopores with charged walls

2008-03-04

arxiv.org/abs/0803.0483v2

Phys. Rev. E 78, 032901 (2008)

Biology

Quantitative Biology

Subcellular Processes

3 pages, 1 figure

Scientific paper

10.1103/PhysRevE.78.032901

Translocation of a single stranded DNA through genetically engineered $\alpha$-hemolysin channels with positively charged walls is studied. It is predicted that transport properties of such channels are dramatically different from neutral wild type $\alpha$-hemolysin channel. We assume that the wall charges compensate the fraction $x$ of the bare charge $q_{b}$ of the DNA piece residing in the channel. Our prediction are as follows (i) At small concentration of salt the blocked ion current decreases with $x$. (ii) The effective charge $q$ of DNA piece, which is very small at $x = 0$ (neutral channel) grows with $x$ and at $x=1$ reaches $q_{b}$. (iii) The rate of DNA capture by the channel exponentially grows with $x$. Our theory is also applicable to translocation of a double stranded DNA in narrow solid state nanopores with positively charged walls.

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