The Role of Family-Based Designs in Genome-Wide Association Studies

Details The Role of Family-Based Designs in Genome-Wide Association Studies The Role of Family-Based Designs in Genome-Wide Association Studies

2010-10-22

arxiv.org/abs/1010.4629v1

Statistical Science 2009, Vol. 24, No. 4, 388-397

Statistics

Methodology

Published in at http://dx.doi.org/10.1214/08-STS280 the Statistical Science (http://www.imstat.org/sts/) by the Institute of M

Scientific paper

10.1214/08-STS280

Genome-Wide Association Studies (GWAS) offer an exciting and promising new research avenue for finding genes for complex diseases. Traditional case-control and cohort studies offer many advantages for such designs. Family-based association designs have long been attractive for their robustness properties, but robustness can mean a loss of power. In this paper we discuss some of the special features of family designs and their relevance in the era of GWAS.

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