The postmitotic Saccharomyces cerevisiae after spaceflight showed higher viability

Details The postmitotic Saccharomyces cerevisiae after spaceflight showed higher viability The postmitotic Saccharomyces cerevisiae after spaceflight showed higher viability

Jun 2011

adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=2011adspr..47.2049y&link_type=abstract

Advances in Space Research, Volume 47, Issue 11, p. 2049-2057.

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The budding yeast Saccharomyces cerevisiae has been proposed as an ideal model organism for clarifying the biological effects caused by spaceflight conditions. The postmitotic S. cerevisiae cells onboard Practice eight recoverable satellite were subjected to spaceflight for 15 days. After recovery, the viability, the glycogen content, the activities of carbohydrate metabolism enzymes, the DNA content and the lipid peroxidation level in yeast cells were analyzed. The viability of the postmitotic yeast cells after spaceflight showed a three-fold increase as compared with that of the ground control cells. Compared to the ground control cells, the lipid peroxidation level in the spaceflight yeast cells markedly decreased. The spaceflight yeast cells also showed an increase in G2/M cell population and a decrease in Sub-G1 cell population. The glycogen content and the activities of hexokinase and succinate dehydrogenase significantly decreased in the yeast cells after spaceflight. In contrast, the activity of malate dehydrogenase showed an obvious increase after spaceflight. These results suggested that microgravity or spaceflight could promote the survival of postmitotic S. cerevisiae cells through regulating carbohydrate metabolism, ROS level and cell cycle progression.

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