Biology – Quantitative Biology – Genomics
Scientific paper
2008-12-22
Biology
Quantitative Biology
Genomics
18 pages, 5 figures
Scientific paper
Eukaryotic cells are often exposed to fluctuations in growth conditions as well as endogenous and exogenous stress-related agents. In addition, during development global patterns of gene transcription change dramatically, and these changes are associated with altered patterns of DNA replication. In metazoan embryos, for example, transcription is repressed globally and any sequence in the genome can serve as a site for the start of DNA synthesis. As transcription is activated and a G1 phase imposed, the pattern of replication adapts to these changes by restricting the sites where DNA synthesis begins. Recent evidence indicates that each unit of replication, or replicon, is specified by two or more potential replication origins, but only one is selected to initiate replication of the replicon. How the cell distinguishes between potential origins, and how it selects a given origin of replication remain unclear. This raises important questions concerning the nature and definition of the eukaryotic replicon. In the following we will review emerging evidence concerning the mechanisms involved in regulating replication origins during both the normal and perturbed eukaryotic cell cycle.
No associations
LandOfFree
The Dynamic Replicon: adapting to a changing cellular environment does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.
If you have personal experience with The Dynamic Replicon: adapting to a changing cellular environment, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and The Dynamic Replicon: adapting to a changing cellular environment will most certainly appreciate the feedback.
Profile ID: LFWR-SCP-O-539427