Computer Science – Artificial Intelligence
Scientific paper
2010-04-29
Proceedings of the 9th Annual Workshop on Computational Intelligence (UKCI 2009), Nottingham, UK, p13-18,
Computer Science
Artificial Intelligence
6 pages, 2 figures, 1 table, 9th Annual Workshop on Computational Intelligence (UKCI 2009), Nottingham, UK
Scientific paper
The study of immune system aging, i.e. immunosenescence, is a relatively new research topic. It deals with understanding the processes of immunodegradation that indicate signs of functionality loss possibly leading to death. Even though it is not possible to prevent immunosenescence, there is great benefit in comprehending its causes, which may help to reverse some of the damage done and thus improve life expectancy. One of the main factors influencing the process of immunosenescence is the number and phenotypical variety of naive T cells in an individual. This work presents a review of immunosenescence, proposes system dynamics modelling of the processes involving the maintenance of the naive T cell repertoire and presents some preliminary results.
Aickelin Uwe
Figueredo Grazziela P.
Whitbrook Amanda
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