SUMO Substrates and Sites Prediction Combining Pattern Recognition and Phylogenetic Conservation

Details SUMO Substrates and Sites Prediction Combining Pattern Recognition and Phylogenetic Conservation SUMO Substrates and Sites Prediction Combining Pattern Recognition and Phylogenetic Conservation

2004-09-09

arxiv.org/abs/q-bio/0409011v1

Biology

Quantitative Biology

Genomics

15 pages (including 1 figure and 2 tables)

Scientific paper

Small Ubiquitin-related modifier (SUMO) proteins are widely expressed in eukaryotic cells, which are reversibly coupled to their substrates by motif recognition, called sumoylation. Two interesting questions are 1) how many potential SUMO substrates may be included in mammalian proteomes, such as human and mouse, 2) and given a SUMO substrate, can we recognize its sumoylation sites? To answer these two questions, previous prediction systems of SUMO substrates mainly adopted the pattern recognition methods, which could get high sensitivity with relatively too many potential false positives. So we use phylogenetic conservation between mouse and human to reduce the number of potential false positives.

Affiliated with

Also associated with

No associations

Rating

SUMO Substrates and Sites Prediction Combining Pattern Recognition and Phylogenetic Conservation does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.

If you have personal experience with SUMO Substrates and Sites Prediction Combining Pattern Recognition and Phylogenetic Conservation, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and SUMO Substrates and Sites Prediction Combining Pattern Recognition and Phylogenetic Conservation will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFWR-SCP-O-229857