Suggested Role of Lysosomal Lipid in the Contrasting Effects of `Triton WR-1339' and Dextran on Tuberculous Infection

Details Suggested Role of Lysosomal Lipid in the Contrasting Effects of `Triton WR-1339' and Dextran on Tuberculous Infection Suggested Role of Lysosomal Lipid in the Contrasting Effects of `Triton WR-1339' and Dextran on Tuberculous Infection

May 1969

adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=1969natur.222..672h&link_type=abstract

Nature, Volume 222, Issue 5194, pp. 672-673 (1969).

Mathematics

Logic

Scientific paper

THE non-ionic surface-active agent `Triton WR-1339' retards the development of experimental tuberculosis when injected into mice; furthermore, bacterial multiplication is slowed in peritoneal macrophages isolated from rabbits and guinea-pigs previously treated with this substance and infected in tissue culture with Mycobacterium tuberculosis. The chemically related agent `Macrocyclon', which is less toxic than `WR-1339' and can be used directly in tissue culture, is as effective as `WR-1339' in the living mouse and is also active when added to mouse peritoneal macrophages before or after intracellular infection1-3. Dextran, on the other hand, accelerates the intracellular growth of tubercle bacilli when added to similar macrophage cultures3. These substances are thought to act on the cell rather than the bacterium1,3; because they probably accumulate in the macrophage lysosomes3 it seemed logical to examine the possible role of these organelles in tuberculous infection. In particular we wished to know whether any of the constituents of the detergent-containing and dextran-containing lysosomes would show inhibitory or other effects on the bacilli cultured in vitro, in the absence of macrophages.

Affiliated with

Also associated with

No associations

Rating

Suggested Role of Lysosomal Lipid in the Contrasting Effects of `Triton WR-1339' and Dextran on Tuberculous Infection does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.

If you have personal experience with Suggested Role of Lysosomal Lipid in the Contrasting Effects of `Triton WR-1339' and Dextran on Tuberculous Infection, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Suggested Role of Lysosomal Lipid in the Contrasting Effects of `Triton WR-1339' and Dextran on Tuberculous Infection will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFWR-SCP-O-1390288