Computer Science
Scientific paper
Sep 1987
adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=1987orli...17..431r&link_type=abstract
Origins of Life and Evolution of the Biosphere, Volume 17, Issue 3-4, pp. 431-438
Computer Science
Scientific paper
The molecular mechanisms underlying the primitive translational apparatus have been studied in light of present day protein biosynthesis. Using the structural information available from the contemporary system as a key to its function, both the structural necessities for an early adaptor and the multipoint recognition properties of such adaptors have been investigated. This was done by first critically examining the potential feasibility of right- and left-handed hairpin adaptor models. Second, a molecular model of the contemporary transpeptidation complex has been constructed in order to ascertain the structural requirements of the adaptor molecule needed for peptidyl transfer. Third, a model of the tRNATyr-tyrosyl tRNA synthetase complex including the positioning of the disordered region is proposed. This model is used to illustrate those required recognition properties of aminoacyl synthetase which lead to a perspective on the structure of the ancestor synthetase.
McDonald Janece
Raghunathan G.
Rein Robert
Shibata Masaru
Srinivasan Srikant
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