Mathematics – Statistics Theory
Scientific paper
2004-10-05
Annals of Statistics 2004, Vol. 32, No. 4, 1513-1532
Mathematics
Statistics Theory
Published by the Institute of Mathematical Statistics (http://www.imstat.org) in the Annals of Statistics (http://www.imstat
Scientific paper
10.1214/009053604000000517
Thomas' partial likelihood estimator of regression parameters is widely used in the analysis of nested case-control data with Cox's model. This paper proposes a new estimator of the regression parameters, which is consistent and asymptotically normal. Its asymptotic variance is smaller than that of Thomas' estimator away from the null. Unlike some other existing estimators, the proposed estimator does not rely on any more data than strictly necessary for Thomas' estimator and is easily computable from a closed form estimating equation with a unique solution. The variance estimation is obtained as minus the inverse of the derivative of the estimating function and therefore the inference is easily available. A numerical example is provided in support of the theory.
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