Statistical Analysis in Genetic Studies of Mental Illnesses

Details Statistical Analysis in Genetic Studies of Mental Illnesses Statistical Analysis in Genetic Studies of Mental Illnesses

2011-08-16

arxiv.org/abs/1108.3168v1

Statistical Science 2011, Vol. 26, No. 1, 116-129

Statistics

Methodology

Published in at http://dx.doi.org/10.1214/11-STS353 the Statistical Science (http://www.imstat.org/sts/) by the Institute of M

Scientific paper

10.1214/11-STS353

Identifying the risk factors for mental illnesses is of significant public health importance. Diagnosis, stigma associated with mental illnesses, comorbidity, and complex etiologies, among others, make it very challenging to study mental disorders. Genetic studies of mental illnesses date back at least a century ago, beginning with descriptive studies based on Mendelian laws of inheritance. A variety of study designs including twin studies, family studies, linkage analysis, and more recently, genomewide association studies have been employed to study the genetics of mental illnesses, or complex diseases in general. In this paper, I will present the challenges and methods from a statistical perspective and focus on genetic association studies.

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