Some mathematical refinements concerning error minimization in the genetic code

Details Some mathematical refinements concerning error minimization in the genetic code Some mathematical refinements concerning error minimization in the genetic code

2009-09-08

arxiv.org/abs/0909.1442v2

Biology

Quantitative Biology

Quantitative Methods

Substantially revised with respect to the earlier version. Currently in review

Scientific paper

The genetic code has been shown to be very error robust compared to randomly selected codes, but to be significantly less error robust than a certain code found by a heuristic algorithm. We formulate this optimisation problem as a Quadratic Assignment Problem and thus verify that the code found by the heuristic is the global optimum. We also argue that it is strongly misleading to compare the genetic code only with codes sampled from the fixed block model, because the real code space is orders of magnitude larger. We thus enlarge the space from which random codes can be sampled from approximately 2.433 x 10^18 codes to approximately 5.908 x 10^45 codes. We do this by leaving the fixed block model, and using the wobble rules to formulate the characteristics acceptable for a genetic code. By relaxing more constraints three larger spaces are also constructed. Using a modified error function, the genetic code is found to be more error robust compared to a background of randomly generated codes with increasing space size. We point out that these results do not necessarily imply that the code was optimized during evolution for error minimization, but that other mechanisms could explain this error robustness.

Affiliated with

Also associated with

No associations

Rating

Some mathematical refinements concerning error minimization in the genetic code does not yet have a rating. At this time, there are no reviews or comments for this scientific paper.

If you have personal experience with Some mathematical refinements concerning error minimization in the genetic code, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Some mathematical refinements concerning error minimization in the genetic code will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFWR-SCP-O-108082