Single Stranded DNA Translocation Through a Fluctuating Nanopore

Details Single Stranded DNA Translocation Through a Fluctuating Nanopore Single Stranded DNA Translocation Through a Fluctuating Nanopore

2005-01-11

arxiv.org/abs/q-bio/0501014v2

J.T. Fourkas, P. Levitz, M. Urbakh, K.J. Wahl Eds. Dynamics in Small Confining Systems, MRS Proceedings (Boston, 2003)

Biology

Quantitative Biology

Subcellular Processes

6 pages, 3 figures

Scientific paper

We investigate the translocation of a single stranded DNA (ssDNA) through a pore, which fluctuates between two conformations, by using coupled master equations (ME). The probability density function (PDF) of the first passage times (FPT) of the translocation process is calculated, displaying a triple, double or mono-peaked behavior, depending on the system parameters. An analytical expression for the mean first passage time (MFPT) of the translocation process is derived, and provides an extensive characterization of the translocation process.

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