Simulated microgravity does not alter epithelial cell adhesion to matrix and other molecules

Details Simulated microgravity does not alter epithelial cell adhesion to matrix and other molecules Simulated microgravity does not alter epithelial cell adhesion to matrix and other molecules

Publishing date

Aug 1994

URL

adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=1994adspr..14...71j&link_type=abstract

Journals

Advances in Space Research, Volume 14, Issue 8, p. 71-76.

Science

Computer Science

Type

Scientific paper

Abstract

Microgravity has advantages for the cultivation of tissues with high fidelity; however, tissue formation requires cellular recognition and adhesion. We tested the hypothesis that simulated microgravity does not affect cell adhesion. Human colorectal carcinoma cells were cultured in the NASA Rotating Wall Vessel (RWV) under low shear stress with randomization of the gravity vector that simulates microgravity. After 6 - 7 days, cells were assayed for binding to various substrates and compared to cells grown in standard tissue culture flasks and static suspension cultures. The RWV cultures bound as well to basement membrane proteins and to CEA, an intercellular adhesion molecule, as control cultures did. Thus, microgravity does not alter epithelial cell adhesion and may be useful for tissue engineering.

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