Short-range spectroscopic ruler based on a single-molecule optical switch

Details Short-range spectroscopic ruler based on a single-molecule optical switch Short-range spectroscopic ruler based on a single-molecule optical switch

2005-02-14

arxiv.org/abs/q-bio/0502012v1

Biology

Quantitative Biology

Quantitative Methods

Article contains 4 pages and 4 figures. Accepted for publication in Physical Review Letters. Supplementary material and movie

Scientific paper

10.1103/PhysRevLett.94.108101

We demonstrate a novel all-optical switch consisting of two molecules: a primary fluorophore that can be switched between a fluorescent and a dark state by light of different wavelengths, and a secondary chromophore that facilitates switching. The interaction between the two molecules exhibits a distance dependence much steeper than that of Forster resonance energy transfer. This enables the switch to act as a ruler with the capability to probe distances difficult to access by other spectroscopic methods, thus presenting a new tool for the study of biomolecules at the single-molecule level.

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