Sequential recruitment and combinatorial assembling of multiprotein complexes in transcriptional activation

Details Sequential recruitment and combinatorial assembling of multiprotein complexes in transcriptional activation Sequential recruitment and combinatorial assembling of multiprotein complexes in transcriptional activation

2006-05-30

arxiv.org/abs/q-bio/0605049v1

Phys. Rev. Lett. 96, 198102 (2006)

Biology

Quantitative Biology

Cell Behavior

Scientific paper

10.1103/PhysRevLett.96.198102

In human cells, estrogenic signals induce cyclical association and dissociation of specific proteins with the DNA in order to activate transcription of estrogen-responsive genes. These oscillations can be modeled by assuming a large number of sequential reactions represented by linear kinetics with random kinetic rates. Application of the model to experimental data predicts robust binding sequences in which proteins associate with the DNA at several different phases of the oscillation. Our methods circumvent the need to derive detailed kinetic graphs, and are applicable to other oscillatory biological processes involving a large number of sequential steps.

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