Biology – Quantitative Biology – Quantitative Methods
Scientific paper
2007-09-04
Biology
Quantitative Biology
Quantitative Methods
The manuscript is 23 pages long (14 pages of text and 9 of references). It contains five figures, two of which in color
Scientific paper
Schizophrenia is a severe, currently incurable, relatively common mental condition. Its symptoms are complex and widespread. It structurally and functionally affects cortical and subcortical regions involved in cognitive, emotional and motivational aspects of behavior. Its cause is unknown, its diagnosis is based on statistical behavior and its treatment is elusive. Our paradigm addresses the complexity of schizophrenic symptoms. Building upon recent neural vulnerability and limbic dysregulation hypotheses, it offers a mathematical model for the evolution of the limbic system under perturbation. Dependence on parameters and the concept of "bifurcation" could be the key to understanding the threshold between "normality" and "disease".
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