Rule-based Modeling and Simulation of Biochemical Systems with Molecular Finite Automata

Details Rule-based Modeling and Simulation of Biochemical Systems with Molecular Finite Automata Rule-based Modeling and Simulation of Biochemical Systems with Molecular Finite Automata

2010-07-08

arxiv.org/abs/1007.1315v2

Biology

Quantitative Biology

Quantitative Methods

23 pages, 6 figures

Scientific paper

We propose a theoretical formalism, molecular finite automata (MFA), to describe individual proteins as rule-based computing machines. The MFA formalism provides a framework for modeling individual protein behaviors and systems-level dynamics via construction of programmable and executable machines. Models specified within this formalism explicitly represent the context-sensitive dynamics of individual proteins driven by external inputs and represent protein-protein interactions as synchronized machine reconfigurations. Both deterministic and stochastic simulations can be applied to quantitatively compute the dynamics of MFA models. We apply the MFA formalism to model and simulate a simple example of a signal transduction system that involves a MAP kinase cascade and a scaffold protein.

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