Robust formation of morphogen gradients

Details Robust formation of morphogen gradients Robust formation of morphogen gradients

2004-12-08

arxiv.org/abs/q-bio/0412014v1

Physical Review Letters 94, 018103 (2005)

Biology

Quantitative Biology

Other Quantitative Biology

Scientific paper

10.1103/PhysRevLett.94.018103

We discuss the formation of graded morphogen profiles in a cell layer by nonlinear transport phenomena, important for patterning developing organisms. We focus on a process termed transcytosis, where morphogen transport results from binding of ligands to receptors on the cell surface, incorporation into the cell and subsequent externalization. Starting from a microscopic model, we derive effective transport equations. We show that, in contrast to morphogen transport by extracellular diffusion, transcytosis leads to robust ligand profiles which are insensitive to the rate of ligand production.

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