Rigidity sensing explained by active matter theory

Biology – Quantitative Biology – Quantitative Methods

Scientific paper

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4 pages, 2 figures

Scientific paper

10.1016/j.bpj.2011.08.023

The magnitude of traction forces exerted by living animal cells on their
environment is a monotonically increasing and approximately sigmoidal function
of the stiffness of the external medium. This observation is rationalized using
active matter theory: adaptation to substrate rigidity results from an
interplay between passive elasticity and active contractility.

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