Regression of a Radioactive Mercurial Diuretic from the Plasma of Man

Details Regression of a Radioactive Mercurial Diuretic from the Plasma of Man Regression of a Radioactive Mercurial Diuretic from the Plasma of Man

Apr 1949

adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=1949natur.163..640r&link_type=abstract

Nature, Volume 163, Issue 4147, pp. 640-641 (1949).

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Scientific paper

DURING the study of the mechanism of chroni congestive heart failure and other œdematous states it became more evident that there is need for a better understanding of the pharmacodynamics o mercurial diuretics. Investigations have been carried out with the use of radioactive mercury incorporated in a mercurial diuretic, `Mercuhydrin' (sodium sal of methoxyoximercuripropylsuccinylurea with theo phylline, prepared in this laboratory by Messrs. H Krahnke, E. Sprengler and D. Kaestner through the courtesy of Dr. H. L. Daiell of Lakeside Laboratories Milwaukee, Wisconsin, with the use of mercury 203-205 from the A.E.C. Oak Ridge Operations), in order to observe for a period of 100-180 min. the concentration-time course of the isotope in the plasma of man after intravenous injection.

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