Reconstruction of Network Evolutionary History from Extant Network Topology and Duplication History

Details Reconstruction of Network Evolutionary History from Extant Network Topology and Duplication History Reconstruction of Network Evolutionary History from Extant Network Topology and Duplication History

2012-03-12

arxiv.org/abs/1203.2430v1

Biology

Quantitative Biology

Populations and Evolution

15 pages, 5 figures, submitted to ISBRA 2012

Scientific paper

Genome-wide protein-protein interaction (PPI) data are readily available thanks to recent breakthroughs in biotechnology. However, PPI networks of extant organisms are only snapshots of the network evolution. How to infer the whole evolution history becomes a challenging problem in computational biology. In this paper, we present a likelihood-based approach to inferring network evolution history from the topology of PPI networks and the duplication relationship among the paralogs. Simulations show that our approach outperforms the existing ones in terms of the accuracy of reconstruction. Moreover, the growth parameters of several real PPI networks estimated by our method are more consistent with the ones predicted in literature.

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