Rare coding SNP in DZIP1 gene associated with late-onset sporadic Parkinson's disease

Details Rare coding SNP in DZIP1 gene associated with late-onset sporadic Parkinson's disease Rare coding SNP in DZIP1 gene associated with late-onset sporadic Parkinson's disease

2011-08-31

arxiv.org/abs/1109.0029v2

Biology

Quantitative Biology

Genomics

14 pages

Scientific paper

We present the first application of the hypothesis-rich mathematical theory to genome-wide association data. The Hamza et al. late-onset sporadic Parkinson's disease genome-wide association study dataset was analyzed. We found a rare, coding, non-synonymous SNP variant in the gene DZIP1 that confers increased susceptibility to Parkinson's disease. The association of DZIP1 with Parkinson's disease is consistent with a Parkinson's disease stem-cell ageing theory.

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