R Factors Mediate Resistance to Mercury, Nickel, and Cobalt

Details R Factors Mediate Resistance to Mercury, Nickel, and Cobalt R Factors Mediate Resistance to Mercury, Nickel, and Cobalt

May 1967

adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=1967sci...156.1114s&link_type=abstract

Science, Volume 156, Issue 3778, pp. 1114-1116

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Scientific paper

Fifty-five clinical isolates and laboratory stocks of Escherichia coli and Salmonella were studied for resistance to each of ten metals. Eleven clinical isolates carrying R factors were resistant to mercury, and, in each case, the resistance was mediated by a previously undefined R-factor gene. The gene was phenotypically expressed within 2 to 4 minutes after entry into sensitive bacteria, but the basis for the resistance remains undefined. Fourteen strains, 12 infected with R factors, were resistant to cobalt and nickel, but these resistances were mediated by R-factor genes in only two strains; separate R-factor genes mediated the resistances to nickel and cobalt. These and other results indicate that the genetic composition of R factors is greater than that originally defined.

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