Biology – Quantitative Biology – Neurons and Cognition
Scientific paper
2009-06-11
Biology
Quantitative Biology
Neurons and Cognition
8 pages, 5 figures, accepted in Phys. Rev. E
Scientific paper
Variability in neural responses is an ubiquitous phenomenon in neurons, usually modeled with stochastic differential equations. In particular, stochastic integrate-and-fire models are widely used to simplify theoretical studies. The statistical properties of the generated spikes depend on the stimulating input current. Given that real sensory neurons are driven by time-dependent signals, here we study how the inter-spike interval distribution of integrate-and-fire neurons depends on the evolution of the stimulus, in a quasi-static limit. We obtain a closed-form expression for this distribution, and we compare it to the one obtained with numerical simulations for several time-dependent currents. For slow inputs, the quasi-static distribution provides a very good description of the data. The results obtained for the integrate-and-fire model can be extended to other non-autonomous stochastic systems where the first passage time problem has an explicit solution.
Samengo Inés
Urdapilleta Eugenio
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