Quantitative model for efficient temporal targeting of tumor cells and neovasculature

Details Quantitative model for efficient temporal targeting of tumor cells and neovasculature Quantitative model for efficient temporal targeting of tumor cells and neovasculature

2010-12-20

arxiv.org/abs/1012.4403v1

Computational and Mathematical Methods in Medicine, Vol. 2011 (2011), Article ID 790721

Biology

Quantitative Biology

Tissues and Organs

17 pages, 5 figures

Scientific paper

10.1155/2011/790721

The combination of cytotoxic therapies and anti-angiogenic agents is emerging as a most promising strategy in the treatment of malignant tumors. However, the timing and sequencing of these treatments seem to play essential roles in achieving a synergic outcome. Using a mathematical modeling approach that is grounded on available experimental data, we investigate the spatial and temporal targeting of tumor cells and neovasculature with a nanoscale delivery system. Our model suggests that the experimental success of the nanoscale delivery system depends crucially on the trapping of chemotherapeutic agents within the tumor tissue. The numerical results also indicate that substantial further improvements in the efficiency of the nanoscale delivery system can be achieved through an adjustment of the temporal targeting mechanism.

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