Protein folding rates correlate with heterogeneity of folding mechanism

Details Protein folding rates correlate with heterogeneity of folding mechanism Protein folding rates correlate with heterogeneity of folding mechanism

2004-07-14

arxiv.org/abs/q-bio/0407022v1

Biology

Quantitative Biology

Quantitative Methods

11 pages, 3 figures, 1 table

Scientific paper

10.1103/PhysRevLett.93.208105

By observing trends in the folding kinetics of experimental 2-state proteins at their transition midpoints, and by observing trends in the barrier heights of numerous simulations of coarse grained, C-alpha model, Go proteins, we show that folding rates correlate with the degree of heterogeneity in the formation of native contacts. Statistically significant correlations are observed between folding rates and measures of heterogeneity inherent in the native topology, as well as between rates and the variance in the distribution of either experimentally measured or simulated phi-values.

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