Programmable models of growth and mutation of cancer-cell populations

Details Programmable models of growth and mutation of cancer-cell populations Programmable models of growth and mutation of cancer-cell populations

2011-09-07

arxiv.org/abs/1109.1364v1

EPTCS 67, 2011, pp. 19-33

Computer Science

Computational Engineering, Finance, and Science

In Proceedings CompMod 2011, arXiv:1109.1044

Scientific paper

10.4204/EPTCS.67.4

In this paper we propose a systematic approach to construct mathematical models describing populations of cancer-cells at different stages of disease development. The methodology we propose is based on stochastic Concurrent Constraint Programming, a flexible stochastic modelling language. The methodology is tested on (and partially motivated by) the study of prostate cancer. In particular, we prove how our method is suitable to systematically reconstruct different mathematical models of prostate cancer growth - together with interactions with different kinds of hormone therapy - at different levels of refinement.

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