Production and action of cytokines in space

Details Production and action of cytokines in space Production and action of cytokines in space

Aug 1994

adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=1994adspr..14r...5c&link_type=abstract

Advances in Space Research, Volume 14, Issue 8, p. 5-9.

Computer Science

1

Scientific paper

B6MP102 cells, a continuously cultured murine bone marrow macrophage cell line, were tested for secretion of tumor necrosis factor-α and Interleukin-1 during space flight. We found that B6MP102 cells secreted more tumor necrosis factor-α and interleukin-1 when stimulated in space with lipopolysaccharide than controls similarly stimulated on earth. This compared to increased secretion of interferon-beta and -gamma by lymphocytes that was measured on the same shuttle flights. Although space flight enhanced B6MP102 secretion of tumor necrosis factor-α, an experiment on a subsequent space flight (STS-50) found that cellular cytotoxicity, mediated by tumor necrosis factor-α, was inhibited.

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