Statistics – Applications
Scientific paper
Dec 2008
adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=2008agufm.p51a1388o&link_type=abstract
American Geophysical Union, Fall Meeting 2008, abstract #P51A-1388
Statistics
Applications
0424 Biosignatures And Proxies, 1023 Composition Of The Biosphere, 1055 Organic And Biogenic Geochemistry, 1094 Instruments And Techniques, 5794 Instruments And Techniques
Scientific paper
Less than a decade ago, protein sequencing was the bane of paleobiology. Since that time researchers have completely sequenced proteins in >50 Ka fossils, been dazzled by reports of collagen peptides in dinosaur bones, and witnessed the development of phylogenetic trees from ancient protein sequences. Enlisting proteomics as biosignature is now in our grasp. In this talk the pitfalls and challenges of mass spectrometric approaches to protein sequencing will be illustrated and phylogenetic applications will be discussed. Work on extinct organisms at Michigan State University, University of Michigan and York University will provide a vantage point to assess methodologies, explore diagenetic alterations, evaluate mass spectra and illustrate issues associated with data base searching. Challenges encountered in the study of paleoproteomics, such as the absence of sequences for extinct organisms in commercially available databases, protein diagenesis and low concentrations of target are parallel to those that will be encountered when protein sequencing is extended to extreme and extraterrestrial environments. Thus, lessons learned from interrogating the ancient proteome are important and necessary step in developing proteomics as a biosignature tools.
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