Biology – Quantitative Biology – Neurons and Cognition
Scientific paper
2004-07-06
Journal of Physiology - Paris 98 (2004) 442--451
Biology
Quantitative Biology
Neurons and Cognition
20 pages, 5 figures
Scientific paper
10.1016/j.jphysparis.2005.09.010
Reduced models of neuronal activity such as Integrate-and-Fire models allow a description of neuronal dynamics in simple, intuitive terms and are easy to simulate numerically. We present a method to fit an Integrate-and-Fire-type model of neuronal activity, namely a modified version of the Spike Response Model, to a detailed Hodgkin-Huxley-type neuron model driven by stochastic spike arrival. In the Hogkin-Huxley model, spike arrival at the synapse is modeled by a change of synaptic conductance. For such conductance spike input, more than 70% of the postsynaptic action potentials can be predicted with the correct timing by the Integrate-and-Fire-type model. The modified Spike Response Model is based upon a linearized theory of conductance-driven Integrate-and-Fire neuron.
Gerstner Wulfram
Jolivet Renaud
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