Power and limitations of electrophoretic separations in proteomics strategies

Details Power and limitations of electrophoretic separations in proteomics strategies Power and limitations of electrophoretic separations in proteomics strategies

2009-09-23

arxiv.org/abs/0909.4158v1

Mass Spectrometry Reviews 28, 5 (2009) 816-43

Biology

Quantitative Biology

Genomics

Scientific paper

10.1002/mas.20204

Proteomics can be defined as the large-scale analysis of proteins. Due to the complexity of biological systems, it is required to concatenate various separation techniques prior to mass spectrometry. These techniques, dealing with proteins or peptides, can rely on chromatography or electrophoresis. In this review, the electrophoretic techniques are under scrutiny. Their principles are recalled, and their applications for peptide and protein separations are presented and critically discussed. In addition, the features that are specific to gel electrophoresis and that interplay with mass spectrometry (i.e., protein detection after electrophoresis, and the process leading from a gel piece to a solution of peptides) are also discussed.

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