Biology – Quantitative Biology – Subcellular Processes
Scientific paper
2011-12-11
Biology
Quantitative Biology
Subcellular Processes
27 pages, submitted to J. Stat. Phys. special issue
Scientific paper
I consider the microscopic mechanisms by which a particular left-right (L/R) asymmetry is generated at the organism level from the microscopic handedness of cytoskeletal molecules. In light of a fundamental symmetry principle, the typical pattern-formation mechanisms of diffusion plus regulation cannot implement the "right-hand rule"; in fact, the cytoskeleton (made of helical fibers) seems always to be involved, usually in collective states induced by molecular motors. I detail a possible scenario involving actin/myosin layers in snails (and in {\it C. elegans}), and outline other mechanisms which might govern handedness in eukaryote cell motility and in plants.
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